Publications


Click here for a current list in PubMed.



2017


Surve SV, Jensen BC, Heestand M, Mazet M, Smith TK, Bringaud F, Parsons M, Schnaufer A (2017). NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms.
Mol Biochem Parasitol., 211:57-61.
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2016


Eze AA, Gould MK, Munday JC, Tagoe DN, Stelmanis V, Schnaufer A, De Koning HP (2016). Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase. PLoS Negl Trop Dis. 2016 Aug 12;10(8):e0004791.
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Trikin R, Doiron N, Hoffmann A, Haenni B, Jakob M, Schnaufer A, Schimanski B, Zuber B, Ochsenreiter T (2016). TAC102 Is a Novel Component of the Mitochondrial Genome Segregation Machinery in Trypanosomes. PLoS Pathog. 2016 May 11;12(5):e1005586.
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Cuypers B, Lecordier L, Meehan CJ, Van den Broeck F, Imamura H, Büscher P, Dujardin JC, Laukens K, Schnaufer A, Dewar C, Lewis M, Balmer O, Azurago T, Kyei-Faried S, Ohene SA, Duah B, Homiah P, Mensah EK, Anleah F, Franco JR, Pays E, Deborggraeve S (2016). Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection. MBio. 2016 Apr 12;7(2). pii: e02198-15.
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Grewal JS, McLuskey K, Das D, Myburgh E, Wilkes J, Brown E, Lemgruber L, Gould MK, Burchmore RJ, Coombs GH, Schnaufer A, Mottram JC (2016). PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast. J Biol Chem. 2016 Apr 29;291(18):9492-500.
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Zimmermann S, Hall L, Riley S, Sørensen J, Amaro RE, Schnaufer A (2016). A novel high-throughput activity assay for the Trypanosoma brucei editosome enzyme REL1 and other RNA ligases. Nucleic Acids Res., 44(3):e24.
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2015


Carnes J, Anupama A, Balmer O, Jackson A, Lewis M, Brown R, Cestari I, Desquesnes M, Gendrin C, Hertz-Fowler C, Imamura H, Ivens A, Kořený L, Lai DH, MacLeod A, McDermott SM, Merritt C, Monnerat S, Moon W, Myler P, Phan I, Ramasamy G, Sivam D, Lun ZR, Lukeš J, Stuart K, Schnaufer AC (2015). Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty.
PLoS Negl Trop Dis., 9(1):e3404.
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2014


Schnarwiler F, Niemann M, Doiron N, Harsman A, Käser S, Mani J, Chanfon A, Dewar CE, Oeljeklaus S, Jackson CB, Pusnik M, Schmidt O, Meisinger C, Hiller S, Warscheid B, Schnaufer AC, Ochsenreiter T, Schneider A. (2014). Trypanosomal TAC40 constitutes a novel subclass of mitochondrial β-barrel proteins specialized in mitochondrial genome inheritance.
PNAS, 111(21):7624-9.
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Gould MK, Schnaufer AC (2014). Independence from Kinetoplast DNA maintenance and expression is associated with multidrug resistance in Trypanosoma brucei in vitro.
Antimicrob Agents Chemother, 58(5):2925-8. Epub 2014 Feb 18.
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2013


Dean S*, Gould MK*, Dewar C, Schnaufer AC (2013). Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes.
PNAS, 110(36):14741-6. Epub 2013 Aug 19. * joint first authors
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Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M, de Koning HP (2013). Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNAi library screening for resistance to the phosphodiesterase inhibitor Cpd A.
Antimicrob Agents Chemother, 57(10):4882-93. Epub 2013 Jul 22.
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Inoue M, Yasuda K, Uemura H, Yasaka N, Schnaufer A*, Yano M, Kido H, Kohda D, Doi H, Fukuma T, Tsuji A, Horikoshi N (2013). Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo. J Biochem, 153(5):431-93. Epub 2013 Mar 1.
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2012


Carnes J*, Schnaufer A*, McDermott SM, Domingo G, Proff R, Steinberg AG, Kurtz I, Stuart K (2012). Mutational analysis of Trypanosoma brucei editosome proteins KREPB4 and KREPB5 reveals domains critical for function.
RNA, 18(10):1897-909. Epub 2012 Aug 23. * joint first authors
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Lerch M, Carnes J, Acestor N, Guo X, Schnaufer A, Stuart K (2012). Editosome accessory factors KREPB9 and KREPB10 in Trypanosoma brucei.
Eukaryot Cell, 11(7):832-43. Epub 2012 May 4.
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Surve S, Heestand M, Panicucci B, Schnaufer A*, Parsons M* (2012). Enigmatic Presence of Mitochondrial Complex I in Trypanosoma brucei Bloodstream Forms.
Eukaryot Cell, 11(2):183-93. Epub 2011 Dec 9. * joint corresponding authors
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2010


Schnaufer A (2010). Evolution of dyskinetoplastic trypanosomes: how, and how often?
Trends in Parasitology, 26(12):557-8.
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Durrant JD, Hall L, Swift RV, Landon M, Schnaufer A*, Amaro RE* (2010). Novel Naphthalene-Based Inhibitors of Trypanosoma brucei RNA Editing Ligase 1.
PLoS Neglected Tropical Diseases, 4(8).pii: e803. * joint corresponding authors
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Schnaufer A, Wu M, Park Y, Nakai T, Deng J, Proff R, Hol W, Stuart K (2010). A protein-protein interaction map of trypanosome ~20S editosomes.
Journal of Biological Chemistry, 285(8):5282-95.
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2009


Zikova A, Schnaufer A, Dalley R, Panigrahi A, Stuart K (2009). Characterization of the essential multi-subunit F0F1-ATP synthase complex in procyclic Trypanosoma brucei.
PLoS Pathogens, 5(5):e1000436.
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2008


Amaro RE*, Schnaufer A*, Interthal H, Hol W, Stuart K, McCammon A (2008). Discovery of inhibitors against an essential RNA editing ligase in Trypanosoma brucei.
PNAS, 105(45):17278-83.* joint first and corresponding authors
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Tarun SZ Jr, Schnaufer A, Ernst NL, Proff R, Deng J, Hol W, Stuart K (2008). KREPA6, a core component of the 20S editosome, is a general RNA binding protein important for complex integrity and growth in Trypanosoma brucei procyclics.
RNA, 14:347-58.
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2007

Panigrahi AK, Schnaufer A, Stuart K (2007). Isolation and compositional analysis of trypanosomatid editosomes.
Methods in Enzymology, 424:3-24.
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Babbarwal VK, Fleck M, Ernst NL, Schnaufer A, Stuart K (2007). An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei.
RNA, 13:737-44.
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2005

Schnaufer A*, Clark-Walker GD, Steinberg AG, Stuart K* (2005). The F1-ATP synthase complex in bloodstream stage trypanosomes has an unusual and essential function.
EMBO Journal, 24:4029-40. * joint corresponding authors
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Stuart K, Schnaufer A, Ernst NL, Panigrahi A (2005). Complex management: RNA editing in trypanosomes.
Trends in Biochemical Sciences, 30:97-105.
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Inoue M, Nakamura Y, Yasuda K, Yasaka N, Hara T, Schnaufer A, Stuart K, Fukuma T (2005). The 14-3-3 proteins of Trypanosoma brucei function in motility, cytokinesis and cell cycle.
Journal of Biological Chemistry, 280:14085-96.
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2004

Deng J, Schnaufer A, Salavati R, Stuart K, Hol WGJ (2004). High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1.
Journal of Molecular Biology, 343:601-13.
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Stuart K, Panigrahi A, Schnaufer A (2004). Identification and characterization of trypanosome RNA editing complex components.
Methods in Molecular Biology, 265:273-91.


2003

Worthey EA, Schnaufer A, Mian IS, Stuart K, Salavati R (2003). Comparative analysis of editosome proteins in trypanosomatids.
Nucleic Acids Research, 31:6392-408.
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Schnaufer A, Ernst NL, Palazzo SS, O'Rear J, Salavati R, Stuart K (2003). Separate insertion and deletion sub-complexes of the Trypanosoma brucei RNA editing complex.
Molecular Cell, 12:307-19.
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Worthey EA, Martinez-Calvillo S, Schnaufer A, Aggarwal G, Cawthra J, Fazelinia G, Fong C, Fu G, Hassebrock M, Hixson G, Ivens AC, Kiser P, Marsolini F, Rickel E, Salavati R, Sisk E, Sunkin SM, Stuart KD, Myler PJ (2003). Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene.
Nucleic Acids Research, 31:4201-10.
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Panigrahi AK, Schnaufer A, Ernst NL, Wang B, Carmean N, Salavati R, Stuart K (2003). Identification of novel components of Trypanosoma brucei editosomes.
RNA, 9:484-92.
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2002

Furuya T, Kessler P, Jardim A, Schnaufer A, Crudder C, Parsons M (2002). Glucose is toxic to glycosome-deficient trypanosomes.
Proceedings of the National Academy of Sciences U S A, 99:14177-82.
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Schnaufer A*, Domingo GJ, Stuart K (2002). Natural and induced dyskinetoplastic trypanosomatids: How to live without mitochondrial DNA.
International Journal for Parasitology, 32:1071-84. * corresponding author
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Stuart K, Panigrahi AK, Schnaufer A, Drodz M, Clayton C, Salavati R (2002). Composition of the editing complex of Trypanosoma brucei.
Philosophical Transactions of The Royal Society, London, B, Biological Sciences, 357:71-9.
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Yan S, Martinez-Calvillo S, Schnaufer A, Myler PJ, Stuart K (2002). A low-background inducible promoter system in Leishmania donovani.
Molecular and Biochemical Parasitology, 119:217-23.
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2001

Panigrahi AK, Schnaufer A, Carmean N, Igo RP, Gygi SP, Ernst NL, Palazzo SS, Weston DS, Aebersold R, Salavati R, Stuart K (2001). Four related proteins of the Trypanosoma brucei RNA editing complex.
Molecular and Cellular Biology, 21:6833-40.
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Schnaufer A, Panigrahi AK, Panicucci B, Igo RP Jr, Salavati R, Stuart K. (2001). An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei.
Science, 291:2159-62.
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Panigrahi AK, Gygi SP, Ernst NL, Igo RP, Palazzo S, Schnaufer A, Weston DS, Carmean N, Salavati R, Aebersold R, Stuart K (2001). Association of two novel proteins TbMP52 and TbMP48 with the Trypanosoma brucei RNA editing complex.
Molecular and Cellular Biology, 21:380-9.
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2000

Myler PJ, Sisk E, McDonagh PD, Martinez-Calvillo S, Schnaufer A, Sunkin SM, Yan S, Madhubala R, Ivens A, Stuart K (2000). Genomic organization and gene function in Leishmania.
Biochemical Society Transactions, 28:527-31.

Schnaufer A, Sbicego S, Blum B (2000). Antimycin A resistance in a mutant Leishmania tarentolae strain is correlated to a point mutation in the mitochondrial apocytochrome b gene.
Current Genetics, 37:234-41.
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1998

Sbicego S, Schnaufer A, Blum B (1998). Transient and stable transfection of Leishmania by particle bombardment.
Molecular and Biochemical Parasitology, 94:123-6.
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1995

Hirzmann J, Schnaufer A, Hintz M, Conraths F, Stirm S, Zahner H, Hobom G (1995). Brugia spp. and Litomosoides carinii: Identification of a covalently cross-linked microfilarial sheath matrix protein.
Molecular and Biochemical Parasitology, 70:95-106.
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